Leucoreduction: The best method of preventing side effect of contaminated WBCs

Leukocytes in erythrocyte and platelet concentration can be considered as a  contamination during blood transfusion that may lead to serious morbidity and even mortality and cause many undesirable adverse effects as following:

l The transmission of cell-associated infectious agents

l Febrile non-haemolytic reactions

l Graft-vesus-host disease

l Immunosuppression

To prevent or minimize these adverse effects, Leucoreduction filters are used commonly as the best cost-effective solution that the United Sates, many Europe and some other countries have now decided to leukodeplete all cellular blood components.